【作者】 杨帆；

【导师】 刘卫平；

【作者基本信息】 四川大学 ， 病理学与病理生理学， 2006， 博士

【摘要】 人结外鼻型NK／T细胞淋巴瘤(Human Nasal type NK／T celllymphoma)是一类具有特殊形态、免疫表型和生物学行为，多原发于淋巴结外器官或组织，存在高水平EB病毒感染的肿瘤。该肿瘤常表达T细胞分化抗原及自然杀伤(Natural Killer，NK)细胞相关抗原，故此得名。目前认为T细胞、NK细胞具有共同始祖细胞(P-T／NT细胞)，在不同条件下可向T细胞或NK细胞分化。人结外鼻型NK／T细胞淋巴瘤可能来源于具有双向分化潜能的P-T／NT细胞，其瘤细胞的分化已超越前体细胞阶段(P-T／NT细胞、P-T细胞和P-NK细胞)，但尚未达到成熟T淋巴细胞或NK细胞的阶段。新版WHO关于淋巴造血组织肿瘤的分类已将其列为一个独立的淋巴瘤类型。人结外鼻型NK／T细胞淋巴瘤在亚洲及南美洲发病率较高，西欧和北美地区少见，故该肿瘤是亚洲、也是中国的“特产”。四川大学华西医院病理科每年诊断该类肿瘤60余例，约占所有淋巴瘤的13.85％，约占非霍奇金淋巴瘤的16％。 人结外鼻型NK／T细胞淋巴瘤多发于中线面部，局部活检组织多较小，除做病理诊断和免疫表型检测外所剩无几，故实验材料的匮乏严重制约该肿瘤的深入研究。 我课题组经过三年多的工作成功建立人结外鼻型NK／T细胞淋巴瘤更多还原

【Abstract】 Nasal type NK/T cell lymphoma is a primary extranodal lymphoma with special morphology, immunophenotype and biological behavior, and which is highly associated with Epstein-Barr Virus (EBV) infection. The tumor cells are usually express of both T-cell differentiation antigens and NK cell associated antigens. So far, it has been acknowledged that T-cell and NK cell share the same progenitor, which differentiates to T-cell or NK cell under different condition. Because the tumor original from the early stage of the progenitor’s differentiation, nasal type NK/T cell lymphoma is used to identify the tumor now. It has been listed as an entity of lymphoma in the World Health Organization Classification for Tumors of Haematopoitic and Lymphoid Tissues published in 2001. Nasal type NK/T cell lymphoma occupies a relatively higher incidence in Asia and South America regions than that of in Europe and North America, so that it is a special entity in Asia and also in China. About 60 cases of the tumor are newly diagnosed each year; it occupies about 13.83% of all lymphoma cases and 15.85% of all non-Hodgkin lymphoma cases in the Department of pathology West China更多还原