【作者】 黄曙；

【导师】 周建伟；

【作者基本信息】 南京医科大学 ， 劳动卫生与环境卫生学， 2006， 博士

【摘要】 血液细胞分化的调节紊乱导致了白血病的发生。目前，对于调节细胞分化的相关机制仍知之甚少。白血病细胞在一些化学物诱导下能够重新返回特定的定向分化路径。特别是全反式维甲酸(ATRA)在白血病的诱导分化治疗方面取得了巨大成功，开创了癌症治疗的崭新领域——诱导分化疗法。JWA(AF070523)基因是本课题组周建伟等首次发现并克隆的受ATRA诱导的基因。那么，JWA基因是否与ATRA诱导白血病细胞的分化调节有关呢?为此，本研究将致力于探讨JWA基因在人类白血病细胞定向诱导分化调节中的作用。 目的 探讨JWA基因在人类髓系白血病细胞定向分化调节中的作用以及分化诱导剂调控JWA表达的机制，为进一步深入了解白血病的发生、发展过程并为白血病的预防、诊断和治疗提供新的科学依据。更多还原

【Abstract】 Dysregulation of hematopoietic cellular differentiation contributes to leukemogenesis. Neoplastic myeloid cells are derived from cells, which diverse from the nature differentiating pathway at distinct developmental stages, most often as myeloblasts or promyelocytes. The common feature of these neoplastic cells is their capacity to return to the differentiation pathway by exposure to certain chemical agents. Some of them have been already used clinically. Unfortunately, relatively little is known about how cell differentiation is regulated. JWA (AF070523) is a novel all-trans retinoic acid (ATRA) responsible gene that was initially isolated from ATRA-treated primary human tracheal bronchial epithelial cells. For the notable performance achieved by ATRA in the differentiation induction therapy, we investigated the role of JWA in the induction of differentiation of human myeloid leukemia cells.更多还原