【作者】 王远红；

【导师】 东贵荣；

【作者基本信息】 黑龙江中医药大学 ， 针灸推拿学， 2005， 博士

【摘要】 本课题综述中外古今有关银屑病临床防治机理研究文献,根据导师学术思想,在多年临床实践总结基础上,建立了一种行之有效的治疗银屑病的非药物疗法,即五脏俞刺血拔罐法。本课题对122例寻常型银屑病进行了临床疗效观察及实验研究,其中治疗组68例,对照组54例,通过临床组间对比观察,并采用PASI评分方法,以证实五脏俞刺血拔罐法治疗寻常型银屑病的有效性及安全性,并使该疗法规范化。采用酶联免疫法及放射免疫法血清学等方法对银屑病患者血清肿瘤坏死因子—α、白细胞介素—2、白细胞介素—2R、白细胞介素—6、细胞间粘附分子—Ⅰ、粒细胞集落刺激因子、内皮素等指标进行了检测分析,以探讨五脏俞刺血拔罐法的治疗有效性及作用环节机理。研究结果表明:1.五脏俞刺血拔罐法对寻常型银屑病有显著疗效,且优于对照组,其总有效率为94.12%,显效率51.47%。临床证实该法在改善红斑、浸润、鳞屑,减轻皮损程度及面积等方面,有良好效果。表明该法具清泄血热、疏通经络、通达表里、调理脏腑阴阳等作用,该法具有简便廉验等特点,临床易于推广应用。2.五脏俞刺血拔罐法有抑制表皮过度角化,减轻角化不全,改善真皮乳头水肿及血管扩张,减轻白细胞浸润,减轻炎症反应等皮损病理形态作用。3.银屑病患者血清肿瘤坏死因子—α水平升高。五脏俞刺血拔罐法有降低血清TNF—α浓度,减轻银屑病皮损严重程度和单核细胞浸润度之作用。4.银屑病患者血清白介素—Ⅱ浓度与皮损程度呈正相关。五脏俞刺血拔罐法有降低血清IL—2浓度的作用。5.银屑病患者血清白介素-Ⅱ受体水平上调,五脏俞刺血拔罐法可使其水平下调。6.血清IL-6水平与病变范围和严重程度呈正相关,银屑病患者血清白介素-6水平升高,而五脏俞刺血拔罐法则具有使其降低的作用。7.银屑病患者血清G-CSF水平升高,五脏俞刺血拔罐法可使其血清水平下降。8.五脏俞刺血拔罐更多还原

【Abstract】 A review of neurodermatitis (lichen simplex chronicus, psoriasis vulgaris) was done to understand, the underlying mechanism of the disease, how to prevent it, and the therapies used in clinical practice. A clinical method, "Wu Zang Shu" pinpricking with cupping has been studied to treat neurodermatitis (without the use of another therapy (i.e. topical or internal medicine)) and was proven to be effective. Clinical research on 122 patients with neurodermatitis was undertaken. There were 68 patients in the treatment group and 54 patients in the control group. A comparison between the two groups, using the PASI method, was done. The work objectively confirmed the effectiveness of the therapeutic method in treating neurodermatitis. ELISA, RIA and serum testing of TNF-α, IL-2, IL-2R, IL-6, sICAM-Ⅰ, rhG-CSF, and endothlin were used to understand the mechanism of the therapy of the Wu Zang Shu pinpricking and cupping. The results show that: 1.) The method was an effective treatment when compared to the control group with an efficacy rate of 94.1%. Clinical practice confirmed that the method improves the erythema and infiltration scales, relieving the degree and area of the lesion. It also showed that the method clears heat in the blood, clear the channels, clears the superficial and interior, and regulates visceral Yin and Yang. 2.) This method controls lichenification in the epidermis. Relieves lichenification, improves dermis nipple edema, and vasodilatation by relieving the WBC infiltration and inflammation reactions. 3.) The level of TNF-α in the disease treatment group’s serum. This method can lower the TNF-α and relieve the degree of lesion and monocyte infiltration. 4.) The neurodermatitis treatment group serum IL-2 concentration reduced after treatment. 5.) This method reduces the serum IL-2R of the treatment whose level of IL-2R has risen. 6.) This method can lower the serum IL-6 of the neurodermatitis patients’ whose level of IL-6 has risen. 7.) This method can lower the serum G-SCF of the neurodermatitis patients whose level of G-SCF has risen. 8.) This method can reduce the level of sICM- I and adjust the intercellular adhesion and inflammation reaction. 9.) This method can also reduce the serum ET of neurodermatitis patients whose level of ET has risen, improving the skin’s microcirculation. 10) the research observed the effect on the TNF-α, IL-2, IL-2R, IL-6, sICAM- I , rhG-CSF, ET in the neurodermatitis patients’ blood by Wu Zang Shu pinpricking with cupping method ,It shows that the method can adjust the immunication relieving the inflammation reaction improving the skin’s microcirculation relieving the degree of更多还原