【作者】 刘晓然；

【导师】 贺安之； 陆建； 倪晓武；

【作者基本信息】 南京理工大学 ， 光学工程， 2001， 博士

【摘要】 本文在弱激光血管内照射疗法(ILLLIT)治疗前后全血黏度、血浆黏度、红细胞聚集指数、红细胞沉降率(血沉)、红细胞变形及刚性指数、血小板聚集指数和纤维蛋白原等血液流变学指标均有显著改善的临床应用结果的基础上，对该治疗方法的治疗机理，特别对激光与血液中主要成份的相互作用机理进行了理论研究，从而初步解释了弱激光血管内照射疗法的治疗机理。 首先根据弱激光照射疗法的特点，建立了弱激光与氢键相互作用的量子力学模型，研究了弱激光照射对红细胞聚集程度的影响。理论研究结果显示在进行治疗时，照射的激光束将与红细胞之间氢键发生相互作用，进而导致该氢键的断裂，致使红细胞聚集体的逐渐离解，明显改善了红细胞之间的高聚集性，从而能降低低切变率(低切)下的全血黏度和红细胞沉降率(血沉)。 首次采用分形理论和标度关系，建立了蛋白质分子的弹性模量与谱维数的分形模型，研究了弱激光对红细胞膜变形能力的影响。研究结果显示激光光子能量将使红细胞膜中蛋白质分子的电子能级发生变化进而产生构象变化，使得蛋白质分子的谱维数增加，进而减少红细胞膜的弹性模量，显著提高了红细胞的变形能力，同时降低了高切变率(高切)下全血黏度。 根据电子—构像相互作用理论，建立了弱激光与血液中纤维蛋白溶解系统相互作用的量子力学模型，研究了弱激光对血液中纤维蛋白原水平的影响，得到弱激光的作用将提高血浆中的纤维蛋白溶酶的含量，进而使得纤维蛋白原含量减少，改善了血浆黏度，并降低血小板聚集性，从而有利于血栓的溶解。 本文还就Nd：YAG激光对未成熟期白内障进行眼晶状体透明皮质乳化术物理机理进行了理论研究。更多还原

【Abstract】 Based on the clinic results that the intravascular low-reaction-level laser irradiation therapy (ILLLIT) can greatly improve the index of hemortheologic characteristics, theoretic study of this therapy mechanism was made, especially the mechanism of the interaction between laser and the main component of blood so that we give out the primary explanation of ILLLIT mechanism.First of all, according to the characteristics of ILLLIT, the quantum mechanical model of interaction between low-reaction-ievel laser and H-baud is established. What’s more, the influence of low-reaction-level laser to crytlirocyte aggregation index is studies. The theoretic results show that the H-band of erythrocyte will break if it is further irradiated by laser, which will results in the gradual ionization of erythrocyte congeries and reduction of erythrocyte f-ggrctiation index. In this way, the index of whole blood viscosity iow share ami crythrocyle sedimentation rate are improved significantly.In this paper, we first introduce fractal theory combining with the scale relation. We establish the fractal form of protein molecule’s clastic modulus and fracton dimensionality. The influence of low-reaction-level laser to erythrocyte defonnabilily is also investigated. The analysis shows that due to laser photon energy making the protein molecules’ electron energy level of erythrocyte changed, the protein molecules’ fracton dimensionality increase. It further decreases the erythrocyte’s elastic modulus. In this way, we can explain the reason that the erythrocyte deformability enhances by ILLLIT while the whole blood viscosity in high share decreases.According to the theory of electron-conformation interaction, we establish the quantum mechanical model of the relation between low-reaction-level laser and Plasminogen-Plasmin system. We also study the influence of low-reaction-level laser to blood fibrinogen. Hereby the conclusions are drawed that the low-reaction-level laser can increases the content of fibrinolysis so that fibrinogen is diseased. As the result, the plasma viscosity and the degree of blood platelets’ aggregation are reduced which can explain the improvement of thrombus dissolution by the treatment of ILLLIT.At last, we also study the theoretical analysis of critical hyaline cortex emulsification with Nd:YAG laser.更多还原