【摘要】 从豆科植物蔓性千斤拔[Flemingia philippinensis（Merr.et Rolfe）Li]的根中分得六个化合物和一个烷酸的混合物（Ⅰ～Ⅶ）。经理化常数测定和光谱分析证明,化合物Ⅰ和Ⅱ为新化合物,分别命名为蔓性千斤拔素C（Ⅰ）和蔓性千斤拔素D（Ⅱ）,其余为已知物,分别鉴定为5,7,3′,4′-四羟基-6,8-双异戊烯基异黄酮（Ⅲ）,flemichin D（Ⅳ）,n C₂₂～C₃₀烷酸（Ⅴ）,β-谷甾醇（Ⅵ）和羽扇豆醇（Ⅶ）。化合物Ⅲ和Ⅳ对P₃₈₈白血病细胞具有显著的抑制作用。更多还原

【Abstract】 Two new prenylated flavonoids, flemiphilippinin C（Ⅰ） and flemiphilippinin D （Ⅱ） have been isolated from the root of Flemingia philippinensis （Merr. et Rolfe）Li along with four known compounds. The structure of Ⅰ and Ⅱ were elucidated as 7 - （4′-hydroxy-3′-methoxyphenyl） - 5 - hydroxy - 2, 2 - dimethyl - 10 - prenyl - 2H, 6H - benzo - [1, 2 - b: 5, 4 - b′] dipyran - 6 - one and 5, 7, 2′, 4′ - tetrahydroxy - 6, 8- diprenylflavanone respectively, on the basis of chemical and spectroscopic data, The four known compounds were identified as 5, 7, 3′, 4′-tetrahydroxy-6, 8-diprenylisoflavone （Ⅲ）, flemichin D （Ⅳ）, β-sitosterol （Ⅵ） and lupeol （Ⅶ）. and a mixture of n C₂₂～C₃₀ aliphatic acid （Ⅴ）. Compounds Ⅲ and Ⅳ showed significant cytotoxic activities against P₃₈₈ cell cultures.更多还原